Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Encephalopathy
ADR ID BADD_A01462
ADR Hierarchy
17      Nervous system disorders
17.13      Encephalopathies
17.13.02      Encephalopathies NEC
17.13.02.001      Encephalopathy
Description A disorder characterized by a pathologic process involving the brain. [CTCAE] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM. [MeSH]
MedDRA Code 10014625
MeSH ID D001927
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Encephalopathy | Encephalopathy acute | Encephalopathy chronic | Encephalopathy NOS | Encephalopathy, unspecified | Influenza encephalopathy | Brain Diseases | Brain Disease | Brain Disorders | Brain Disorder | Intracranial CNS Disorders | Central Nervous System Intracranial Disorders | CNS Disorders, Intracranial | CNS Disorder, Intracranial | Intracranial CNS Disorder | Encephalon Diseases | Encephalon Disease | Intracranial Central Nervous System Disorders | Central Nervous System Disorders, Intracranial | Encephalopathies
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Dihydropyrimidine dehydrogenase [NADP(+)]Q12882T75890
Gamma-aminobutyric acid receptor subunit beta-1P15431Not Available
TransketolaseP29401T67754
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02053Sofosbuvir0.013020%
BADD_D02058Sorafenib0.006927%
BADD_D02066Spironolactone0.000519%
BADD_D02093Sulfasalazine--
BADD_D02100Sunitinib--
BADD_D02105Tacrolimus0.030517%
BADD_D02147Telmisartan0.001280%
BADD_D02150Temozolomide0.001332%
BADD_D02155Tenofovir disoproxil0.017772%
BADD_D02192Thalidomide--
BADD_D02203Thiotepa--
BADD_D02210Tiagabine--
BADD_D02211Tiagabine hydrochloride--
BADD_D02241Tolcapone--
BADD_D02246Tolvaptan0.000563%
BADD_D02247Topiramate0.000718%
BADD_D02254Tramadol0.000094%
BADD_D02268Treprostinil--
BADD_D02270Tretinoin--
BADD_D02307Trovafloxacin--
BADD_D02308Trovafloxacin mesylate--
BADD_D02319Urofollitropin--
BADD_D02323Valacyclovir--
BADD_D02324Valacyclovir hydrochloride--
BADD_D02329Valproic acid0.008636%
BADD_D02331Valsartan0.000579%
BADD_D02334Vandetanib0.000533%
BADD_D02344Vemurafenib0.001083%
BADD_D02346Venlafaxine0.002012%
BADD_D02355Vigabatrin--
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